ISSN: 1001-0602
EISSN: 1748-7838
2012 impact factor 10.526*
(Thomson Reuters, 2013)
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VOLUME 29 ISSUE 9(9,2019): 687-689

 

Towards precise, safe genome editing

 

Sebastian Memczak 1,2, Yanjiao Shao 1,3 and Juan Carlos Izpisua Belmonte 1

 

1 Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; 2Paul F. Glenn Center for Biology of Aging Research at the Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA and 3Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jeronimos N135,12 Guadalupe, CA 30107, Spain

Correspondence:Juan Carlos Izpisua Belmonte (belmonte@salk.edu)        

 

Commonly used Cas9:gRNA programmed base-editor complexes introduce frequent, so far unrecognized RNA off-target edits. Novel, engineered enzymes may overcome this hurdle towards clinical applications of genome engineering.

 

https://doi.org/10.1038/s41422-019-0188-x

 
 
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