ISSN: 1001-0602
EISSN: 1748-7838
2012 impact factor 10.526*
(Thomson Reuters, 2013)
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VOLUME 29 ISSUE 9(9,2019): 690-691


Lnc(ing) interferon production and action


Ganes C. Sen1 and Bryan R. G. Williams 1,2


1 Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA and 2Hudson Institute of Medical Research and Department of Molecular and Translational Science, Monash University, Clayton, Australia

Correspondence:Ganes C. Sen (        


Host-virus homeostasis is intricately regulated at multiple steps of both interferon (IFN) induction and IFN action; a recent paper by Zhou et al. has revealed a new feature of this complex regulation. They report the discovery of an IFN-inducible cytoplasmic long non-coding RNA, lncLrrc55-AS, which promotes IRF3 phosphorylation by inactivating the phosphatase PP2A, thus providing a positive feedback loop to IFN induction.

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