ISSN: 1001-0602
EISSN: 1748-7838
2012 impact factor 10.526*
(Thomson Reuters, 2013)
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VOLUME 29 ISSUE 9(9,2019): 692-693

 

Interferon-γ induces cancer cell ferroptosis

 

Laurence Zitvogel 1,2,3 and Guido Kroemer 4,5,6,7,8

 

1Gustave Roussy Cancer Campus (GRCC), Villejuif, France; 2National Institute of Health and Medical Research (INSERM) U1015, Villejuif, France; 3Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France; 4Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France; 5Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; 6Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; 7Suzhou Institute for Systems Biology, Chinese Academy of Sciences, Suzhou, China and 8 Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, Sweden

Correspondence:Guido Kroemer (kroemer@orange.fr)        

 

Ferroptosis is an atypical cell death modality involving the oxidative destruction of cellular membranes following the failure of a glutathione-dependent antioxidant system. A recent paper by Wang et al. demonstrates that interferon-γ produced by tumor-infiltrating T cells can kill cancer cells through the induction of ferroptosis.

 

https://doi.org/10.1038/s41422-019-0186-z

 
 
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