VOLUME 29 ISSUE 9（9,2019）： 692-693

Interferon-γ induces cancer cell ferroptosis

Laurence Zitvogel ^1,2,3 and Guido Kroemer ^4,5,6,7,8

¹Gustave Roussy Cancer Campus (GRCC), Villejuif, France; ²National Institute of Health and Medical Research (INSERM) U1015, Villejuif, France; ³Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France; ⁴Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France; ⁵Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; ⁶Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; ⁷Suzhou Institute for Systems Biology, Chinese Academy of Sciences, Suzhou, China and 8 Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, Sweden

Correspondence:Guido Kroemer (kroemer@orange.fr)        

Ferroptosis is an atypical cell death modality involving the oxidative destruction of cellular membranes following the failure of a glutathione-dependent antioxidant system. A recent paper by Wang et al. demonstrates that interferon-γ produced by tumor-infiltrating T cells can kill cancer cells through the induction of ferroptosis.

https://doi.org/10.1038/s41422-019-0186-z