1The Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA and 2Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
Correspondence:Jerry L. Workman (JLW@stowers.org)
Recent studies have demonstrated the addition and removal of a smorgasbord of site-specific acylation modifications on lysine residues of histone tails. The study by Zhang et al. now shows how the SIRT3 histone deacylase exhibits class specificity, acting on only a subset of β-hydroxybutyrylated lysines.